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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619569
Species: Homo sapiens
RGD Object: Gene
Symbol: ABCC2
Name: ATP binding cassette subfamily C member 2
Acc ID: CHEBI:18293
Term: 5-methoxypsoralen
Definition: A 5-methoxyfurocoumarin that is psoralen substituted by a methoxy group at position 5.
Chemical ID: MESH:C022909
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ABCC2decreases activityEXP 6480464CTD5-methoxypsoralen results in decreased activity of ABCC2 proteinPMID:29079042
ABCC2decreases expressionEXP 6480464CTD5-methoxypsoralen results in decreased expression of ABCC2 mRNAPMID:29079042
ABCC2multiple interactionsEXP 6480464CTD[5-methoxypsoralen results in decreased activity of ABCC2 protein] which results in decreased export of and results in increased abundance of Daunorubicin; Indomethacin inhibits the reaction [5-methoxypsoralen results in decreased activity of ABCC2 protein]; Indomethacin inhibits the reaction [[5-methoxypsoralen results in decreased activity of ABCC2 protein] which results in decreased export of and results in increased abundance of Daunorubicin]PMID:29079042
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