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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11160
Species: Mus musculus
RGD Object: Gene
Symbol: Prnp
Name: prion protein
Acc ID: CHEBI:18291
Term: manganese atom
Definition: A manganese group element atom that has formula Mn.
Chemical ID: MESH:D008345
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prnpaffects bindingEXP 6480464CTDPRNP protein binds to ManganesePMID:16595185
Prnpincreases stabilityEXP 6480464CTDManganese results in increased stability of PRNP proteinPMID:20176619
Prnpmultiple interactionsEXP 6480464CTD[[PRNP protein binds to Manganese] which co-treated with Hydrogen Peroxide] results in increased cleavage of [PRNP protein binds to PRNP protein]; [[PRNP protein binds to Manganese] which co-treated with Hydrogen Peroxide] results in increased cleavage of PRNP protein; CAT protein inhibits the reaction [[[PRNP protein binds to Manganese] which co-treated with Hydrogen Peroxide] results in increased cleavage of [PRNP protein binds to PRNP protein]]PMID:16595185
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