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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735945
Species: Homo sapiens
RGD Object: Gene
Symbol: CPT1A
Name: carnitine palmitoyltransferase 1A
Acc ID: CHEBI:18258
Term: 3,3',5-triiodo-L-thyronine
Definition: An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.
Chemical ID: MESH:D014284
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CPT1Aincreases expressionEXP 6480464CTDTriiodothyronine results in increased expression of CPT1A mRNAPMID:23209300
CPT1Amultiple interactionsEXP 6480464CTDresveratrol promotes the reaction [Triiodothyronine results in increased expression of CPT1A mRNA]PMID:23209300
CPT1Aincreases expressionISOCpt1a (Rattus norvegicus)6480464CTDTriiodothyronine results in increased expression of CPT1A mRNA; Triiodothyronine results in increased expression of CPT1A proteinPMID:23209300 PMID:34902352
CPT1Amultiple interactionsISOCpt1a (Rattus norvegicus)6480464CTD[BMS201038 co-treated with Triiodothyronine] results in increased expression of CPT1A mRNA; Resveratrol promotes the reaction [Triiodothyronine results in increased expression of CPT1A mRNA]; SIRT1 protein affects the reaction [Triiodothyronine results in increased expression of CPT1A mRNA]; SIRT1 protein affects the reaction [Triiodothyronine results in increased expression of CPT1A protein]; Triiodothyronine promotes the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of CPT1A mRNA]PMID:23209300 PMID:25048947 PMID:34902352
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