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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10474
Species: Mus musculus
RGD Object: Gene
Symbol: Dio1
Name: deiodinase, iodothyronine, type I
Acc ID: CHEBI:18258
Term: 3,3',5-triiodo-L-thyronine
Definition: An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.
Chemical ID: MESH:D014284
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dio1increases expressionEXP 6480464CTDTriiodothyronine results in increased expression of DIO1 mRNAPMID:27420076
Dio1multiple interactionsEXP 6480464CTD2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [Triiodothyronine results in increased expression of DIO1 mRNA]PMID:27420076
Dio1affects abundanceISODIO1 (Homo sapiens)6480464CTDDIO1 gene SNP affects the abundance of TriiodothyroninePMID:17105838
Dio1affects metabolic processingISODio1 (Rattus norvegicus)6480464CTDDIO1 protein affects the metabolism of TriiodothyroninePMID:15254343
Dio1increases chemical synthesisISODIO1 (Homo sapiens)6480464CTDDIO1 protein results in increased chemical synthesis of TriiodothyroninePMID:16131326
Dio1increases expressionISODio1 (Rattus norvegicus)6480464CTDTriiodothyronine results in increased expression of DIO1 mRNAPMID:18288313 PMID:24001430 PMID:25646720 PMID:28167136 PMID:29357290
Dio1increases expressionISODIO1 (Homo sapiens)6480464CTDTriiodothyronine results in increased expression of DIO1PMID:16131326
Dio1multiple interactionsISODio1 (Rattus norvegicus)6480464CTDArsenic affects the reaction [Triiodothyronine results in increased expression of DIO1 mRNA]; Pentachlorophenol inhibits the reaction [Triiodothyronine results in increased expression of DIO1 mRNA]PMID:18288313 PMID:24001430
Dio1multiple interactionsISODIO1 (Homo sapiens)6480464CTD[DIO1 protein co-treated with DIO2 protein co-treated with DIO3 protein] affects the abundance of Triiodothyronine; [DIO1 protein results in increased metabolism of Thyroxine] which results in increased abundance of Triiodothyronine; Iodoacetates inhibits the reaction [[DIO1 protein results in increased metabolism of Thyroxine] which results in increased abundance of Triiodothyronine]PMID:21565810 PMID:23397585
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