GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | TFRC | affects binding | EXP | | 6480464 | CTD | [Iron binds to TF protein] which binds to TFRC protein; [TF protein binds to Iron] which binds to TFRC protein | PMID:16564538 PMID:19859668 | TFRC | increases expression | EXP | | 6480464 | CTD | Iron results in increased expression of TFRC protein | PMID:16988136 | TFRC | increases uptake | EXP | | 6480464 | CTD | TFRC protein results in increased uptake of Iron | PMID:17101452 PMID:34648132 | TFRC | multiple interactions | EXP | | 6480464 | CTD | [Deferoxamine results in decreased abundance of Iron] which results in increased expression of TFRC mRNA; [ferric ammonium citrate results in decreased abundance of Iron] which results in increased expression of TFRC mRNA; [Fluvastatin results in decreased expression of TFRC protein] which results in decreased uptake of Iron; [GGTI 298 results in decreased expression of TFRC protein] which results in decreased uptake of Iron; [Hemin results in decreased abundance of Iron] which results in increased expression of TFRC mRNA; [Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TFRC protein; [TFRC protein results in increased uptake of Iron] which results in increased abundance of Lipid Peroxides; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TFRC protein]; Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TFRC protein]; HFE protein inhibits the reaction [TFRC protein results in increased uptake of Iron] | PMID:10085150 PMID:12393473 PMID:24964743 PMID:33285147 PMID:34648132 | TFRC | affects expression | ISO | Tfrc (Rattus norvegicus) | 6480464 | CTD | Iron affects the expression of TFRC mRNA; Iron affects the expression of TFRC protein | PMID:16428268 | TFRC | affects metabolic processing | ISO | Tfrc (Mus musculus) | 6480464 | CTD | TFRC protein affects the metabolism of Iron | PMID:17194590 | TFRC | decreases expression | ISO | Tfrc (Rattus norvegicus) | 6480464 | CTD | Iron results in decreased expression of TFRC mRNA | PMID:11068183 | TFRC | increases expression | ISO | Tfrc (Rattus norvegicus) | 6480464 | CTD | Iron deficiency results in increased expression of TFRC mRNA; Iron deficiency results in increased expression of TFRC protein | PMID:11969379 PMID:16629162 PMID:17060373 PMID:22457245 | TFRC | increases expression | ISO | Tfrc (Mus musculus) | 6480464 | CTD | Iron deficiency results in increased expression of TFRC mRNA; Iron results in increased expression of TFRC mRNA | PMID:23776592 PMID:24569067 | TFRC | increases uptake | ISO | Tfrc (Rattus norvegicus) | 6480464 | CTD | TFRC protein results in increased uptake of Iron | PMID:17091493 | TFRC | multiple interactions | ISO | Tfrc (Rattus norvegicus) | 6480464 | CTD | [Iron co-treated with Diethylnitrosamine co-treated with Copper] results in decreased expression of TFRC mRNA; [Iron co-treated with Diethylnitrosamine] results in decreased expression of TFRC mRNA; [Iron co-treated with Diethylnitrosamine] results in decreased expression of TFRC protein; Clofibrate inhibits the reaction [Iron deficiency results in increased expression of TFRC mRNA] | PMID:11969379 PMID:20302851 | TFRC | multiple interactions | ISO | Tfrc (Mus musculus) | 6480464 | CTD | [CP gene mutant form results in increased abundance of Iron] which results in decreased expression of TFRC mRNA; [Iron co-treated with Ethanol] results in increased expression of TFRC mRNA; [Zinc deficiency results in increased abundance of Iron] which results in increased expression of TFRC mRNA; [Zinc deficiency results in increased abundance of Iron] which results in increased expression of TFRC protein; Iron inhibits the reaction [Diethylnitrosamine results in increased expression of TFRC protein]; Quercetin inhibits the reaction [[Iron co-treated with Ethanol] results in increased expression of TFRC mRNA]; Quercetin inhibits the reaction [Iron results in increased expression of TFRC mRNA] | PMID:16988052 PMID:18073202 PMID:19061943 PMID:24569067 | | ||||||||||||||||||||||
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