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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61898
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Maoa
Name: monoamine oxidase A
Acc ID: CHEBI:18243
Term: dopamine
Definition: Catechol in which the hydrogen at position 4 is substituted by a 2-aminoethyl group.
Chemical ID: MESH:D004298
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases aminationISORGD:7357516480464CTDMAOA protein results in decreased amination of Dopamine

PMID:26721607
increases abundanceISORGD:621916480464CTDMAOA mutant form results in increased abundance of Dopamine

PMID:11834493
multiple interactionsISORGD:7357516480464CTD3, 4-Methylenedioxyamphetamine inhibits the reaction [MAOA protein results in decreased amination of Dopamine], N-Methyl-3, 4-methylenedioxyamphetamine inhibits the reaction [MAOA protein results in decreased amination of Dopamine]

PMID:26721607
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.