GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Prkn | increases expression | ISO | PRKN (Homo sapiens) | 6480464 | CTD | Dopamine results in increased expression of PRKN mRNA | PMID:16987221 | Prkn | multiple interactions | ISO | Prkn (Mus musculus) | 6480464 | CTD | PRKN mutant form results in increased abundance of and results in increased metabolism of Dopamine; PRKN protein affects the abundance of and affects the metabolism of Dopamine; PRKN protein promotes the reaction [Amphetamine results in increased abundance of Dopamine] | PMID:12915482 PMID:15993444 | Prkn | multiple interactions | ISO | PRKN (Homo sapiens) | 6480464 | CTD | PRKN protein inhibits the reaction [Dopamine results in increased abundance of Reactive Oxygen Species]; PRKN protein inhibits the reaction [Dopamine results in increased cleavage of CASP3 protein]; PRKN protein inhibits the reaction [Dopamine results in increased cleavage of PARP1 protein]; PRKN protein inhibits the reaction [Dopamine results in increased phosphorylation of JUN protein] | PMID:15198987 | | ||||||||||||||||||||||
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