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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10511
Species: Mus musculus
RGD Object: Gene
Symbol: Egfr
Name: epidermal growth factor receptor
Acc ID: CHEBI:18231
Term: arsenic acid
Definition: An arsenic oxoacid comprising one oxo group and three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C025657
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Egfrincreases phosphorylationISOEGFR (Homo sapiens)6480464CTDarsenic acid results in increased phosphorylation of EGFR proteinPMID:14674888
Egfrmultiple interactionsISOEGFR (Homo sapiens)6480464CTDEGFR protein affects the reaction [arsenic acid results in increased activity of MAPK1 protein]; EGFR protein affects the reaction [arsenic acid results in increased activity of MAPK3 protein]PMID:14674888
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