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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:18185
Term: gamma-tocopherol
Definition: A tocopherol in which the chroman-6-ol core is substituted by methyl groups at positions 7 and 8. It is found particularly in maize (corn) oil and soya bean (soybean) oils.
Chemical ID: MESH:D024505
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDgamma-Tocopherol results in increased expression of BAX mRNAPMID:31587439
Baxincreases response to substanceISOBAX (Homo sapiens)6480464CTDBAX protein results in increased susceptibility to TocopherolsPMID:16001965
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD[Fluorouracil co-treated with gamma-Tocopherol] results in increased expression of BAX mRNAPMID:31587439
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