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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735711
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP1A2
Name: cytochrome P450 family 1 subfamily A member 2
Acc ID: CHEBI:18145
Term: (R,R,R)-alpha-tocopherol
Definition: An alpha-tocopherol that has R,R,R configuration. The naturally occurring stereoisomer of alpha-tocopherol, it is found particularly in sunflower and olive oils.
Chemical ID: MESH:D024502
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP1A2increases activityISOCyp1a2 (Rattus norvegicus)6480464CTDalpha-Tocopherol results in increased activity of CYP1A2 proteinPMID:15665910
CYP1A2multiple interactionsISOCyp1a2 (Mus musculus)6480464CTDalpha-Tocopherol inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP1A2 mRNA]PMID:26102010
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