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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708392
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp3a9
Name: cytochrome P450, family 3, subfamily a, polypeptide 9
Acc ID: CHEBI:18145
Term: (R,R,R)-alpha-tocopherol
Definition: An alpha-tocopherol that has R,R,R configuration. The naturally occurring stereoisomer of alpha-tocopherol, it is found particularly in sunflower and olive oils.
Chemical ID: MESH:D024502
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp3a9increases expressionISOCyp3a13 (Mus musculus)6480464CTDalpha-Tocopherol results in increased expression of CYP3A13 mRNA; alpha-Tocopherol results in increased expression of CYP3A13 proteinPMID:26102010
Cyp3a9multiple interactionsISOCYP3A5 (Homo sapiens)6480464CTDalpha-Tocopherol inhibits the reaction [CYP3A5 protein results in increased hydroxylation of Testosterone]PMID:31102695
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