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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69168
Species: Homo sapiens
RGD Object: Gene
Symbol: PPARG
Name: peroxisome proliferator activated receptor gamma
Acc ID: CHEBI:18145
Term: (R,R,R)-alpha-tocopherol
Definition: An alpha-tocopherol that has R,R,R configuration. The naturally occurring stereoisomer of alpha-tocopherol, it is found particularly in sunflower and olive oils.
Chemical ID: MESH:D024502
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PPARGincreases activityEXP 6480464CTDalpha-Tocopherol results in increased activity of PPARG proteinPMID:19083475
PPARGincreases expressionEXP 6480464CTDalpha-Tocopherol results in increased expression of PPARG mRNA; alpha-Tocopherol results in increased expression of PPARG proteinPMID:14521714 PMID:28062356
PPARGincreases expressionISOPparg (Rattus norvegicus)6480464CTDalpha-Tocopherol results in increased expression of PPARG proteinPMID:11752099
PPARGmultiple interactionsISOPparg (Rattus norvegicus)6480464CTD[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PPARG mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PPARG protein]PMID:22389237
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