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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62396
Species: Mus musculus
RGD Object: Gene
Symbol: Ddit3
Name: DNA-damage inducible transcript 3
Acc ID: CHEBI:18145
Term: (+)-alpha-tocopherol
Definition: An alpha-tocopherol that has R,R,R configuration. The naturally occurring stereoisomer of alpha-tocopherol, it is found particularly in sunflower and olive oils.
Chemical ID: MESH:D024502
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:691656480464CTDalpha-Tocopherol analog results in increased expression of DDIT3 protein

PMID:20686688
multiple interactionsISORGD:623916480464CTDalpha-Tocopherol inhibits the reaction [Cadmium Chloride results in increased expression of DDIT3 mRNA]

PMID:20459685
multiple interactionsISORGD:691656480464CTDbenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [alpha-Tocopherol analog results in increased expression of DDIT3 protein], DDIT3 mRNA affects the reaction [alpha-Tocopherol analog results in decreased expression of BCL2 protein], salubrinal inhibits the reaction [alpha-Tocopherol analog results in increased expression of DDIT3 protein]

PMID:20686688
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.