GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Hbb | decreases methylation | ISO | HBB (Homo sapiens) | 6480464 | CTD | catechol results in decreased methylation of HBB promoter | PMID:23022512 | Hbb | increases expression | ISO | HBB (Homo sapiens) | 6480464 | CTD | catechol results in increased expression of HBB mRNA | PMID:23022512 PMID:28552822 | Hbb | multiple interactions | ISO | HBB (Homo sapiens) | 6480464 | CTD | [catechol co-treated with Hemin] results in increased expression of HBB mRNA; catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HBB mRNA]; catechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of HBB mRNA]; catechol promotes the reaction [Hemin results in increased expression of HBB mRNA]; COMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of HBB mRNA]; Hemin promotes the reaction [catechol results in increased expression of HBB mRNA] | PMID:24141029 PMID:28552822 | | ||||||||||||||||||||||
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