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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:18123
Term: N-methylnicotinate
Definition: An iminium betaine that is the conjugate base of N-methylnicotinic acid, arising from deprotonation of the carboxy group.
Chemical ID: MESH:C009560
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDtrigonelline inhibits the reaction [ferric citrate results in increased expression of NQO1 protein], trigonelline inhibits the reaction [Pyocyanine results in increased expression of NQO1 mRNA]

PMID:24015256, PMID:29959986
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.