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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10230
Species: Mus musculus
RGD Object: Gene
Symbol: Bcl2
Name: B cell leukemia/lymphoma 2
Acc ID: CHEBI:18123
Term: N-methylnicotinate
Definition: An iminium betaine that is the conjugate base of N-methylnicotinic acid, arising from deprotonation of the carboxy group.
Chemical ID: MESH:C009560
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2multiple interactionsISOBcl2 (Rattus norvegicus)6480464CTDtrigonelline inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased expression of BCL2 protein]PMID:31935362
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTD[trigonelline co-treated with Cisplatin] results in decreased expression of BCL2 protein; [trigonelline co-treated with Etoposide] results in decreased expression of BCL2 proteinPMID:33148531
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