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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3112
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc1
Name: ATP binding cassette subfamily C member 1
Acc ID: CHEBI:18088
Term: formononetin
Definition: A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone substituted by a methoxy group at position 4'.
Chemical ID: MESH:C007768
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc1affects activityISORGD:13446246480464CTDformononetin affects the activity of ABCC1 protein

PMID:15796199
Abcc1decreases expressionISORGD:13446246480464CTDformononetin results in decreased expression of ABCC1 mRNA

PMID:23867903
Abcc1multiple interactionsISORGD:13446246480464CTDAcetylcysteine inhibits the reaction [formononetin results in decreased expression of ABCC1 mRNA] formononetin inhibits the reaction [Epirubicin results in increased expression of ABCC1 mRNA]

PMID:23867903
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