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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2458
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:18088
Term: formononetin
Definition: A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone substituted by a methoxy group at position 4'.
Chemical ID: MESH:C007768
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1decreases methylationISORGD:7308706480464CTDCYP1A1 protein results in decreased methylation of formononetin

PMID:15479032
Cyp1a1increases expressionISORGD:7308706480464CTDformononetin results in increased expression of CYP1A1 mRNA

PMID:28985473
Cyp1a1increases hydroxylationISORGD:7308706480464CTDCYP1A1 protein results in increased hydroxylation of formononetin

PMID:15479032
Cyp1a1multiple interactionsISORGD:7308706480464CTDfulvestrant promotes the reaction [formononetin results in increased expression of CYP1A1 mRNA]

PMID:28985473
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.