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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619868
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gclc
Name: glutamate-cysteine ligase, catalytic subunit
Acc ID: CHEBI:180495
Term: 4-phenyl-3-furoxancarbonitrile
Definition: A 1,2,5-oxadiazole substituted by an oxido, cyano and phenyl groups at positions 2, 3 and 4, respectively. It is a vasodilator and inhibitor of platelet aggregation.
Chemical ID: MESH:C090933
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gclcincreases expressionISOGclc (Mus musculus)6480464CTD4-phenyl-3-furoxancarbonitrile analog results in increased expression of GCLC mRNAPMID:22851183
Gclcincreases expressionISOGCLC (Homo sapiens)6480464CTD4-phenyl-3-furoxancarbonitrile results in increased expression of GCLC mRNAPMID:22851183
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