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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1350859
Species: Homo sapiens
RGD Object: Gene
Symbol: KRAS
Name: KRAS proto-oncogene, GTPase
Acc ID: CHEBI:17967
Term: urethane
Definition: A carbamate ester obtained by the formal condensation of ethanol with carbamic acid. It has been found in alcoholic beverages.
Chemical ID: MESH:D014520
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
KRASdecreases expressionEXP 6480464CTDUrethane results in decreased expression of KRAS mRNAPMID:28818685
KRASaffects response to substanceISOKras (Mus musculus)6480464CTDKRAS gene affects the susceptibility to UrethanePMID:11807781
KRASdecreases expressionISOKras (Mus musculus)6480464CTDUrethane results in decreased expression of KRAS mRNAPMID:16289808
KRASincreases mutagenesisISOKras (Mus musculus)6480464CTDUrethane results in increased mutagenesis of KRAS genePMID:10779650
KRASincreases mutagenesisISOKras (Rattus norvegicus)6480464CTDUrethane results in increased mutagenesis of KRAS genePMID:18271921
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