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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62089
Species: Mus musculus
RGD Object: Gene
Symbol: Prkn
Name: parkin RBR E3 ubiquitin protein ligase
Acc ID: CHEBI:17963
Term: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Definition: A tetrahydropyridine that is 1,2,3,6-tetrahydropyridine substituted by a methyl group at position 1 and a phenyl group at position 4.
Chemical ID: MESH:D015632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prkndecreases expressionEXP 6480464CTD1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PRKN mRNA; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PRKN proteinPMID:23643664 PMID:28978077
Prkndecreases response to substanceEXP 6480464CTDPRKN protein results in decreased susceptibility to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridinePMID:23643664
Prknincreases expressionEXP 6480464CTD1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PRKN mRNA; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PRKN proteinPMID:22342763 PMID:27566062
Prknmultiple interactionsEXP 6480464CTDAM 1241 inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PRKN mRNA]; AM 1241 inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PRKN protein]; PRKN protein inhibits the reaction [PINK1 protein affects the susceptibility to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine]PMID:22511790 PMID:28978077
Prknmultiple interactionsISOPRKN (Homo sapiens)6480464CTDPRKN protein inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH]PMID:25447324
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