Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620640
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2d4
Name: cytochrome P450, family 2, subfamily d, polypeptide 4
Acc ID: CHEBI:17963
Term: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Definition: A tetrahydropyridine that is 1,2,3,6-tetrahydropyridine substituted by a methyl group at position 1 and a phenyl group at position 4.
Chemical ID: MESH:D015632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:7362186480464CTD1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine results in decreased expression of CYP2D22 mRNA, 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine results in decreased expression of CYP2D22 protein

PMID:19594327
increases metabolic processingISORGD:7362176480464CTDCYP2D6 protein results in increased metabolism of 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine

PMID:12464242
multiple interactionsISORGD:7362186480464CTDKetoconazole inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine results in decreased expression of CYP2D22 mRNA]], Ketoconazole inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine results in decreased expression of CYP2D22 protein]], Ketoconazole promotes the reaction [1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine results in decreased expression of CYP2D22 mRNA], Ketoconazole promotes the reaction [1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine results in decreased expression of CYP2D22 protein], Nicotine inhibits the reaction [1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine results in decreased expression of CYP2D22 mRNA], Nicotine inhibits the reaction [1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine results in decreased expression of CYP2D22 protein]

PMID:19594327
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.