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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2581
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1
Acc ID: CHEBI:179285
Term: Isopropylparaben
Definition: null
Chemical ID: MESH:C098802
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1decreases expressionEXP 6480464CTDisopropyl 4-hydroxybenzoate results in decreased expression of ESR1 mRNA; isopropyl 4-hydroxybenzoate results in decreased expression of ESR1 proteinPMID:19654335
Esr1multiple interactionsEXP 6480464CTDFulvestrant inhibits the reaction [isopropyl 4-hydroxybenzoate results in decreased expression of ESR1 mRNA]; Fulvestrant inhibits the reaction [isopropyl 4-hydroxybenzoate results in decreased expression of ESR1 protein]PMID:19654335
Esr1affects bindingISOESR1 (Homo sapiens)6480464CTDisopropyl 4-hydroxybenzoate binds to ESR1 proteinPMID:11193391
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