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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10147
Species: Mus musculus
RGD Object: Gene
Symbol: Alox5
Name: arachidonate 5-lipoxygenase
Acc ID: CHEBI:17924
Term: D-glucitol
Definition: The D-enantiomer of glucitol (also known as D-sorbitol).
Chemical ID: MESH:D013012
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Alox5multiple interactionsISOALOX5 (Homo sapiens)6480464CTD[Sorbitol co-treated with Calcimycin co-treated with Arachidonic Acid] affects the localization of ALOX5 protein; SB 203580 inhibits the reaction [Sorbitol results in increased activity of ALOX5 protein]; Sorbitol results in increased phosphorylation of and results in increased activity of ALOX5 proteinPMID:10779545 PMID:11698504
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