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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1619653
Species: Mus musculus
RGD Object: Gene
Symbol: Ugt1a9
Name: UDP glucuronosyltransferase 1 family, polypeptide A9
Acc ID: CHEBI:17847
Term: p-cresol
Definition: A cresol that consists of toluene substituted by a hydroxy group at position 4. It is a metabolite of aromatic amino acid metabolism produced by intestinal microflora in humans and animals.
Chemical ID: MESH:C032538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ugt1a9increases glucuronidationISOUGT1A9 (Homo sapiens)6480464CTDUGT1A9 protein results in increased glucuronidation of 4-cresolPMID:32421801
Ugt1a9multiple interactionsISOUGT1A9 (Homo sapiens)6480464CTD4-cresol inhibits the reaction [[UGT1A9 protein results in increased glucuronidation of Mycophenolic Acid] which results in increased abundance of mycophenolic acid glucuronide]; [4-cresol inhibits the reaction [[UGT1A9 protein results in increased glucuronidation of Mycophenolic Acid] which results in increased abundance of mycophenolic acid glucuronide]] which results in increased abundance of Mycophenolic Acid; Niflumic Acid inhibits the reaction [UGT1A9 protein results in increased glucuronidation of 4-cresol]PMID:31742356 PMID:32421801
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