GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | ESR1 | affects activity | EXP | | 6480464 | CTD | naringenin affects the activity of ESR1 protein | PMID:15185748 | ESR1 | affects binding | EXP | | 6480464 | CTD | naringenin binds to ESR1 protein | PMID:19913605 PMID:22692793 | ESR1 | decreases expression | EXP | | 6480464 | CTD | naringenin results in decreased expression of ESR1 mRNA; naringenin results in decreased expression of ESR1 mRNA alternative form; naringenin results in decreased expression of ESR1 protein alternative form | PMID:24586459 PMID:30153467 | ESR1 | increases activity | EXP | | 6480464 | CTD | naringenin results in increased activity of ESR1 protein | PMID:10854714 PMID:16118406 | ESR1 | increases expression | EXP | | 6480464 | CTD | naringenin metabolite results in increased expression of ESR1 mRNA; naringenin results in increased expression of ESR1 mRNA | PMID:30153467 PMID:36235125 | ESR1 | multiple interactions | EXP | | 6480464 | CTD | [naringenin binds to ESR1 protein] which results in increased activity of ALPL protein; [naringenin co-treated with bisphenol A] results in increased expression of ESR1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of ESR1 mRNA; [naringenin results in increased phosphorylation of and results in increased activity of ESR1 protein] which results in increased expression of CTSD mRNA; [naringenin results in increased phosphorylation of and results in increased activity of ESR1 protein] which results in increased expression of PGR mRNA; [naringenin results in increased phosphorylation of and results in increased activity of ESR1 protein] which results in increased expression of PSEN2 mRNA; [SB 203580 co-treated with naringenin] results in increased degradation of ESR1 protein; [Tamoxifen co-treated with naringenin] results in decreased expression of ESR1 mRNA; [Tamoxifen co-treated with naringenin] results in decreased expression of ESR1 mRNA alternative form; [Tamoxifen co-treated with naringenin] results in decreased expression of ESR1 protein; [Tamoxifen co-treated with naringenin] results in decreased expression of ESR1 protein alternative form; Fulvestrant inhibits the reaction [[naringenin binds to ESR1 protein] which results in increased activity of ALPL protein]; naringenin binds to and results in increased activity of ESR1 protein; naringenin inhibits the reaction [Cycloheximide results in decreased expression of ESR1 protein]; naringenin inhibits the reaction [Estradiol results in decreased expression of ESR1 protein]; naringenin promotes the reaction [ESR1 protein binds to ESR1 protein]; naringenin results in increased phosphorylation of and results in increased activity of ESR1 protein | PMID:10397250 PMID:12650720 PMID:15713566 PMID:24586459 PMID:30153467 PMID:36235125 PMID:9751507 | ESR1 | affects binding | ISO | Esr1 (Mus musculus) | 6480464 | CTD | naringenin binds to ESR1 protein | PMID:19913605 | ESR1 | affects binding | ISO | Esr1 (Rattus norvegicus) | 6480464 | CTD | naringenin binds to ESR1 protein | PMID:19913605 | |
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