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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736559
Species: Homo sapiens
RGD Object: Gene
Symbol: ESR1
Name: estrogen receptor 1
Acc ID: CHEBI:17846
Term: (S)-naringenin
Definition: The (S)-enantiomer of naringenin.
Chemical ID: MESH:C005273
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ESR1affects activityEXP 6480464CTDnaringenin affects the activity of ESR1 proteinPMID:15185748
ESR1affects bindingEXP 6480464CTDnaringenin binds to ESR1 proteinPMID:19913605 PMID:22692793
ESR1decreases expressionEXP 6480464CTDnaringenin results in decreased expression of ESR1 mRNA; naringenin results in decreased expression of ESR1 mRNA alternative form; naringenin results in decreased expression of ESR1 protein alternative formPMID:24586459 PMID:30153467
ESR1increases activityEXP 6480464CTDnaringenin results in increased activity of ESR1 proteinPMID:10854714 PMID:16118406
ESR1increases expressionEXP 6480464CTDnaringenin metabolite results in increased expression of ESR1 mRNA; naringenin results in increased expression of ESR1 mRNAPMID:30153467 PMID:36235125
ESR1multiple interactionsEXP 6480464CTD[naringenin binds to ESR1 protein] which results in increased activity of ALPL protein; [naringenin co-treated with bisphenol A] results in increased expression of ESR1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of ESR1 mRNA; [naringenin results in increased phosphorylation of and results in increased activity of ESR1 protein] which results in increased expression of CTSD mRNA; [naringenin results in increased phosphorylation of and results in increased activity of ESR1 protein] which results in increased expression of PGR mRNA; [naringenin results in increased phosphorylation of and results in increased activity of ESR1 protein] which results in increased expression of PSEN2 mRNA; [SB 203580 co-treated with naringenin] results in increased degradation of ESR1 protein; [Tamoxifen co-treated with naringenin] results in decreased expression of ESR1 mRNA; [Tamoxifen co-treated with naringenin] results in decreased expression of ESR1 mRNA alternative form; [Tamoxifen co-treated with naringenin] results in decreased expression of ESR1 protein; [Tamoxifen co-treated with naringenin] results in decreased expression of ESR1 protein alternative form; Fulvestrant inhibits the reaction [[naringenin binds to ESR1 protein] which results in increased activity of ALPL protein]; naringenin binds to and results in increased activity of ESR1 protein; naringenin inhibits the reaction [Cycloheximide results in decreased expression of ESR1 protein]; naringenin inhibits the reaction [Estradiol results in decreased expression of ESR1 protein]; naringenin promotes the reaction [ESR1 protein binds to ESR1 protein]; naringenin results in increased phosphorylation of and results in increased activity of ESR1 proteinPMID:10397250 PMID:12650720 PMID:15713566 PMID:24586459 PMID:30153467 PMID:36235125 PMID:9751507
ESR1affects bindingISOEsr1 (Mus musculus)6480464CTDnaringenin binds to ESR1 proteinPMID:19913605
ESR1affects bindingISOEsr1 (Rattus norvegicus)6480464CTDnaringenin binds to ESR1 proteinPMID:19913605
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