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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10552
Species: Mus musculus
RGD Object: Gene
Symbol: Esr2
Name: estrogen receptor 2 (beta)
Acc ID: CHEBI:17846
Term: (S)-naringenin
Definition: The (S)-enantiomer of naringenin.
Chemical ID: MESH:C005273
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects bindingEXP 6480464CTDnaringenin binds to ESR2 protein

PMID:19913605
affects bindingISORGD:25826480464CTDnaringenin binds to ESR2 protein

PMID:19913605
affects bindingISORGD:692136480464CTDnaringenin binds to ESR2 protein

PMID:12224631, PMID:16566672, PMID:19913605
increases activityISORGD:692136480464CTDnaringenin results in increased activity of ESR2 protein

PMID:16118406, PMID:17716812
increases expressionISORGD:692136480464CTDnaringenin results in increased expression of ESR2 mRNA, naringenin results in increased expression of ESR2 protein

PMID:30153467
multiple interactionsISORGD:692136480464CTD[Tamoxifen co-treated with naringenin] results in increased expression of ESR2 mRNA, [Tamoxifen co-treated with naringenin] results in increased expression of ESR2 protein, naringenin binds to and results in increased activity of ESR2 protein, naringenin inhibits the reaction [Estradiol binds to ESR2 protein]

PMID:16566672, PMID:30153467, PMID:9751507
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.