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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10436
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:17846
Term: (S)-naringenin
Definition: The (S)-enantiomer of naringenin.
Chemical ID: MESH:C005273
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1increases expressionEXP 6480464CTDnaringenin results in increased expression of CYP1A1 mRNAPMID:20930378
Cyp1a1multiple interactionsEXP 6480464CTDnaringenin promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]PMID:20930378
Cyp1a1decreases activityISOCyp1a1 (Rattus norvegicus)6480464CTDnaringenin results in decreased activity of CYP1A1 proteinPMID:27444380
Cyp1a1decreases activityISOCYP1A1 (Homo sapiens)6480464CTDnaringenin results in decreased activity of CYP1A1 proteinPMID:21053930 PMID:27444380
Cyp1a1multiple interactionsISOCYP1A1 (Homo sapiens)6480464CTDnaringenin binds to and results in decreased activity of CYP1A1 protein; naringenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]PMID:11454723
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