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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1583689
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ugt1a5
Name: UDP glucuronosyltransferase family 1 member A5
Acc ID: CHEBI:1784
Term: biphenyl-4-amine
Definition: An aminobiphenyl that is biphenyl substituted by an amino group at position 4.
Chemical ID: MESH:C006757
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ugt1a5increases glucuronidationISOUGT1A4 (Homo sapiens)6480464CTDUGT1A4 protein results in increased glucuronidation of 4-biphenylaminePMID:15840509
Ugt1a5multiple interactionsISOUGT1A4 (Homo sapiens)6480464CTD[Alamethicin results in increased activity of UGT1A4 protein] which results in increased glucuronidation of 4-biphenylamine; hecogenin inhibits the reaction [UGT1A4 protein binds to and results in increased glucuronidation of 4-biphenylamine]; UGT1A4 protein binds to and results in increased glucuronidation of 4-biphenylaminePMID:17080401
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