Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1344668
Species: Homo sapiens
RGD Object: Gene
Symbol: NAT1
Name: N-acetyltransferase 1
Acc ID: CHEBI:1784
Term: biphenyl-4-amine
Definition: An aminobiphenyl that is biphenyl substituted by an amino group at position 4.
Chemical ID: MESH:C006757
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NAT1affects response to substanceEXP 6480464CTDNAT1 mRNA alternative form affects the susceptibility to 4-biphenylaminePMID:21837760
NAT1increases acetylationEXP 6480464CTDNAT1 protein polymorphism results in increased acetylation of 4-biphenylamine; NAT1 protein results in increased acetylation of 4-biphenylaminePMID:12088197 PMID:22010219
NAT1increases activityEXP 6480464CTDNAT1 protein results in increased activity of 4-biphenylaminePMID:15450435
NAT1increases response to substanceEXP 6480464CTDNAT1 polymorphism results in increased susceptibility to 4-biphenylamine; NAT1 protein polymorphism results in increased susceptibility to 4-biphenylaminePMID:22010219 PMID:22114069
NAT1multiple interactionsEXP 6480464CTD[NAT1 polymorphism results in increased susceptibility to 4-biphenylamine] which results in increased mutagenesis of HPRT1 genePMID:22114069
NAT1increases metabolic processingISONat1 (Mus musculus)6480464CTDNAT1 protein results in increased metabolism of 4-biphenylaminePMID:16815960
Go Back to source page   Continue to Ontology report