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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732740
Species: Homo sapiens
RGD Object: Gene
Symbol: CAT
Name: catalase
Acc ID: CHEBI:17833
Term: gentamycin
Definition: Any of a group of aminoglycoside antibiotics produced by fermentation of some Micromonospora spp.
Chemical ID: MESH:D005839
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CATdecreases activityISOCat (Rattus norvegicus)6480464CTDGentamicins results in decreased activity of CAT proteinPMID:16671961 PMID:22526374
CATdecreases expressionISOCat (Rattus norvegicus)6480464CTDGentamicins results in decreased expression of CAT mRNA; Gentamicins results in decreased expression of CAT proteinPMID:11033412 PMID:15350274 PMID:20623750 PMID:21081137 PMID:22061828 PMID:3111476
CATincreases activityISOCat (Rattus norvegicus)6480464CTDGentamicins results in increased activity of CAT proteinPMID:17202664
CATmultiple interactionsISOCat (Rattus norvegicus)6480464CTDCAT protein inhibits the reaction [Gentamicins results in increased phosphorylation of and results in increased activity of MAPK8 protein]; Gentamicins results in decreased expression of and results in decreased activity of CAT protein; Melatonin inhibits the reaction [Gentamicins results in decreased activity of CAT protein]; resveratrol inhibits the reaction [Gentamicins results in increased activity of CAT protein]PMID:11033412 PMID:15936777 PMID:17202664 PMID:22526374
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