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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732271
Species: Homo sapiens
RGD Object: Gene
Symbol: MAPK8
Name: mitogen-activated protein kinase 8
Acc ID: CHEBI:17833
Term: gentamycin
Definition: Any of a group of aminoglycoside antibiotics produced by fermentation of some Micromonospora spp.
Chemical ID: MESH:D005839
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MAPK8increases activityISOMapk8 (Rattus norvegicus)6480464CTDGentamicins results in increased activity of MAPK8 proteinPMID:20074632
MAPK8increases phosphorylationISOMapk8 (Rattus norvegicus)6480464CTDGentamicins results in increased phosphorylation of MAPK8 proteinPMID:16401625
MAPK8multiple interactionsISOMapk8 (Rattus norvegicus)6480464CTDCAT protein inhibits the reaction [Gentamicins results in increased phosphorylation of and results in increased activity of MAPK8 protein]; Estradiol inhibits the reaction [Gentamicins results in increased activity of MAPK8 protein]; Gentamicins results in increased phosphorylation of and results in increased activity of MAPK8 protein; icatibant inhibits the reaction [KLK1 protein inhibits the reaction [Gentamicins results in increased phosphorylation of MAPK8 protein]]; KLK1 protein inhibits the reaction [Gentamicins results in increased phosphorylation of MAPK8 protein]; Verapamil inhibits the reaction [Gentamicins results in increased phosphorylation of and results in increased activity of MAPK8 protein]PMID:15936777 PMID:16401625 PMID:20074632
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