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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:17833
Term: gentamycin
Definition: Any of a group of aminoglycoside antibiotics produced by fermentation of some Micromonospora spp.
Chemical ID: MESH:D005839
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxaffects expressionEXP 6480464CTDGentamicins affects the expression of BAX mRNAPMID:26779593
Baxincreases expressionEXP 6480464CTDGentamicins results in increased expression of BAX mRNA; Gentamicins results in increased expression of BAX proteinPMID:19698708 PMID:22526374 PMID:33387578
Baxmultiple interactionsEXP 6480464CTDAmlodipine inhibits the reaction [Gentamicins results in increased expression of BAX protein]; Melatonin inhibits the reaction [Gentamicins results in increased expression of BAX protein]; Nifedipine inhibits the reaction [Gentamicins results in increased expression of BAX protein]; Nitrendipine promotes the reaction [Gentamicins results in increased expression of BAX protein]; Sodium Fluoride affects the reaction [Gentamicins affects the expression of BAX mRNA]PMID:19698708 PMID:22526374 PMID:26779593
Baxincreases expressionISOBax (Mus musculus)6480464CTDGentamicins results in increased expression of BAX mRNA; Gentamicins results in increased expression of BAX proteinPMID:29751043 PMID:31021006
Baxmultiple interactionsISOBax (Mus musculus)6480464CTDbaicalin inhibits the reaction [Gentamicins results in increased expression of BAX mRNA]; baicalin inhibits the reaction [Gentamicins results in increased expression of BAX protein]PMID:31021006
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