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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345007
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP2E1
Name: cytochrome P450 family 2 subfamily E member 1
Acc ID: CHEBI:17824
Term: propan-2-ol
Definition: A secondary alcohol that is propane in which one of the hydrogens attached to the central carbon is substituted by a hydroxy group.
Chemical ID: MESH:D019840
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP2E1increases expressionISOCyp2e1 (Rattus norvegicus)6480464CTD2-Propanol results in increased expression of CYP2E1 proteinPMID:9118891
CYP2E1multiple interactionsISOCyp2e1 (Rattus norvegicus)6480464CTD2-Propanol binds to and results in increased expression of CYP2E1 protein; 2-Propanol inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]PMID:3337723 PMID:7710944
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