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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737309
Species: Homo sapiens
RGD Object: Gene
Symbol: PPARA
Name: peroxisome proliferator activated receptor alpha
Acc ID: CHEBI:17823
Term: calcitriol
Definition: A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.
Chemical ID: MESH:D002117
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PPARAincreases expressionEXP 6480464CTDCalcitriol results in increased expression of PPARA mRNAPMID:19667161 PMID:21592394
PPARAmultiple interactionsEXP 6480464CTD[Calcitriol co-treated with GW 501516] results in increased expression of PPARA mRNA; [Testosterone co-treated with Calcitriol] results in increased expression of PPARA mRNA; Calcitriol promotes the reaction [alpha-Linolenic Acid results in increased expression of PPARA mRNA]; Calcitriol promotes the reaction [Bezafibrate results in increased expression of PPARA mRNA]; Calcitriol promotes the reaction [Docosahexaenoic Acids results in increased expression of PPARA mRNA]; Calcitriol promotes the reaction [pirinixic acid results in increased expression of PPARA mRNA]PMID:19667161 PMID:21592394
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