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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734049
Species: Homo sapiens
RGD Object: Gene
Symbol: COL1A1
Name: collagen type I alpha 1 chain
Acc ID: CHEBI:17823
Term: calcitriol
Definition: A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.
Chemical ID: MESH:D002117
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
COL1A1increases expressionEXP 6480464CTDCalcitriol results in increased expression of COL1A1 mRNA; Calcitriol results in increased expression of COL1A1 proteinPMID:16002434 PMID:17595320 PMID:28105418
COL1A1multiple interactionsEXP 6480464CTDIGFBP5 protein inhibits the reaction [Calcitriol results in increased expression of COL1A1 protein]PMID:17595320
COL1A1increases expressionISOCol1a1 (Rattus norvegicus)6480464CTDCalcitriol results in increased expression of COL1A1 mRNAPMID:16813520
COL1A1increases expressionISOCol1a1 (Mus musculus)6480464CTDCalcitriol results in increased expression of COL1A1 mRNAPMID:16813520
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