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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731067
Species: Mus musculus
RGD Object: Gene
Symbol: Csf1
Name: colony stimulating factor 1 (macrophage)
Acc ID: CHEBI:17823
Term: calcitriol
Definition: A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.
Chemical ID: MESH:D002117
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Csf1decreases expressionISOCSF1 (Homo sapiens)6480464CTDCalcitriol results in decreased expression of CSF1 mRNAPMID:16002434
Csf1increases expressionISOCSF1 (Homo sapiens)6480464CTDCalcitriol results in increased expression of CSF1 mRNAPMID:21592394
Csf1multiple interactionsISOCSF1 (Homo sapiens)6480464CTD[Testosterone co-treated with Calcitriol] results in increased expression of CSF1 mRNAPMID:21592394
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