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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708418
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cd40lg
Name: CD40 ligand
Acc ID: CHEBI:17823
Term: calcitriol
Definition: A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.
Chemical ID: MESH:D002117
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:13529596480464CTD[CD40LG protein co-treated with Calcitriol] results in decreased expression of CD80 protein, [CD40LG protein co-treated with Calcitriol] results in decreased expression of CD86 protein, [CD40LG protein co-treated with Calcitriol] results in decreased secretion of and results in decreased expression of IL1B protein, [CD40LG protein co-treated with Calcitriol] results in decreased secretion of and results in decreased expression of TNF protein

PMID:19186073
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.