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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68556
Species: Homo sapiens
RGD Object: Gene
Symbol: CCND1
Name: cyclin D1
Acc ID: CHEBI:17823
Term: calcitriol
Definition: A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.
Chemical ID: MESH:D002117
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CCND1decreases expressionEXP 6480464CTDCalcitriol results in decreased expression of CCND1 mRNA; Calcitriol results in decreased expression of CCND1 proteinPMID:10825140 PMID:17595320 PMID:21542014 PMID:35914560 PMID:36504884 PMID:9783903
CCND1multiple interactionsEXP 6480464CTD[Calcitriol co-treated with Genistein] results in decreased expression of CCND1 mRNA; [salinomycin co-treated with Calcitriol] results in decreased expression of CCND1 mRNA; Calcitriol inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CCND1 mRNA]; Calcitriol inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CCND1 protein]PMID:15955619 PMID:35914560 PMID:36504884
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