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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619565
Species: Mus musculus
RGD Object: Gene
Symbol: Mapk14
Name: mitogen-activated protein kinase 14
Acc ID: CHEBI:17823
Term: calcitriol
Definition: A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.
Chemical ID: MESH:D002117
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk14increases activityISOMAPK14 (Homo sapiens)6480464CTDCalcitriol results in increased activity of MAPK14 proteinPMID:19748465
Mapk14increases phosphorylationISOMapk14 (Rattus norvegicus)6480464CTDCalcitriol results in increased phosphorylation of MAPK14 proteinPMID:16598785
Mapk14multiple interactionsISOMAPK14 (Homo sapiens)6480464CTD[CAMP results in increased activity of MAPK14] affects the reaction [Calcitriol results in increased expression of ATG5 mRNA]; [CAMP results in increased activity of MAPK14] affects the reaction [Calcitriol results in increased expression of BECN1 mRNA]; CAMP mutant form inhibits the reaction [Calcitriol results in increased activity of MAPK14 protein]PMID:19748465
Mapk14multiple interactionsISOMapk14 (Rattus norvegicus)6480464CTD[Calcitriol co-treated with TGFB1 protein] results in increased phosphorylation of MAPK14 proteinPMID:16598785
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