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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3540
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rb1
Name: RB transcriptional corepressor 1
Acc ID: CHEBI:17823
Term: calcitriol
Definition: A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.
Chemical ID: MESH:D002117
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rb1decreases phosphorylationISORB1 (Homo sapiens)6480464CTDCalcitriol results in decreased phosphorylation of RB1 protein; Calcitriol results in decreased phosphorylation of RB1 protein modified formPMID:10825140 PMID:11270487 PMID:11519864 PMID:12954644 PMID:16039115 PMID:9158000
Rb1increases expressionISORB1 (Homo sapiens)6480464CTDCalcitriol results in increased expression of RB1 mRNA; Calcitriol results in increased expression of RB1 protein; Calcitriol results in increased expression of RB1 protein modified formPMID:14729647 PMID:9348195
Rb1multiple interactionsISORB1 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Calcitriol results in increased expression of RB1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Calcitriol results in increased expression of RB1 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole promotes the reaction [Calcitriol results in increased expression of RB1 mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole promotes the reaction [Calcitriol results in increased expression of RB1 protein]; CSF1R promotes the reaction [Calcitriol results in decreased phosphorylation of RB1 protein]; pyrazolanthrone inhibits the reaction [Calcitriol results in increased expression of RB1 mRNA]; pyrazolanthrone inhibits the reaction [Calcitriol results in increased expression of RB1 protein]; ZK159222 inhibits the reaction [Calcitriol results in increased expression of RB1 protein]PMID:14729647 PMID:9158000
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