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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3419
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Klk6
Name: kallikrein related-peptidase 6
Acc ID: CHEBI:17823
Term: calcitriol
Definition: A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.
Chemical ID: MESH:D002117
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Klk6increases expressionISOKLK6 (Homo sapiens)6480464CTDCalcitriol results in increased expression of KLK6 mRNAPMID:12040012 PMID:16002434 PMID:20206692 PMID:21592394 PMID:26485663
Klk6multiple interactionsISOKLK6 (Homo sapiens)6480464CTD[Testosterone co-treated with Calcitriol] results in increased expression of KLK6 mRNA; Ketoconazole promotes the reaction [Calcitriol results in increased expression of KLK6 mRNA]PMID:21592394 PMID:26485663
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