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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3130
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Myc
Name: MYC proto-oncogene, bHLH transcription factor
Acc ID: CHEBI:17823
Term: calcitriol
Definition: A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.
Chemical ID: MESH:D002117
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mycdecreases expressionISOMYC (Homo sapiens)6480464CTDCalcitriol results in decreased expression of MYC; Calcitriol results in decreased expression of MYC mRNAPMID:12414619 PMID:12875902 PMID:16051482 PMID:21592394 PMID:3093070 PMID:8243807
Mycmultiple interactionsISOMYC (Homo sapiens)6480464CTD[salinomycin co-treated with Calcitriol] results in decreased expression of MYC mRNA; [Testosterone co-treated with Calcitriol] results in decreased expression of MYC mRNAPMID:21592394 PMID:35914560
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