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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2835
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hsd11b2
Name: hydroxysteroid 11-beta dehydrogenase 2
Acc ID: CHEBI:17823
Term: calcitriol
Definition: A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.
Chemical ID: MESH:D002117
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hsd11b2increases expressionISOHSD11B2 (Homo sapiens)6480464CTDCalcitriol results in increased expression of HSD11B2 mRNAPMID:21592394
Hsd11b2multiple interactionsISOHSD11B2 (Homo sapiens)6480464CTD[Testosterone co-treated with Calcitriol] results in increased expression of HSD11B2 mRNAPMID:21592394
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