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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:17823
Term: calcitriol
Definition: A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.
Chemical ID: MESH:D002117
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxdecreases expressionEXP 6480464CTDCalcitriol results in decreased expression of BAX proteinPMID:17570329
Baxmultiple interactionsEXP 6480464CTD2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Calcitriol inhibits the reaction [Streptozocin results in increased expression of BAX protein]]; Calcitriol inhibits the reaction [Streptozocin results in increased expression of BAX protein]PMID:29953732
Baxdecreases expressionISOBAX (Homo sapiens)6480464CTDCalcitriol results in decreased expression of BAX mRNA; Calcitriol results in decreased expression of BAX proteinPMID:21542014 PMID:21592394
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDCalcitriol results in increased expression of BAX mRNA; Calcitriol results in increased expression of BAX proteinPMID:15955619 PMID:31628941
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD[Calcitriol co-treated with Genistein] results in increased expression of BAX mRNA; [Testosterone co-treated with Calcitriol] results in decreased expression of BAX mRNA; Curcumin promotes the reaction [Paclitaxel promotes the reaction [Calcitriol results in increased expression of BAX protein]]; Paclitaxel promotes the reaction [Calcitriol results in increased expression of BAX protein]PMID:15955619 PMID:21592394 PMID:31628941
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