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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1551095
Species: Mus musculus
RGD Object: Gene
Symbol: Rela
Name: v-rel reticuloendotheliosis viral oncogene homolog A (avian)
Acc ID: CHEBI:17823
Term: calcitriol
Definition: A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.
Chemical ID: MESH:D002117
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Relamultiple interactionsEXP 6480464CTDCalcitriol inhibits the reaction [Bleomycin results in increased expression of RELA protein]PMID:26520185
Reladecreases activityISORELA (Homo sapiens)6480464CTDCalcitriol results in decreased activity of RELA proteinPMID:22615136
Reladecreases expressionISORela (Rattus norvegicus)6480464CTDCalcitriol results in decreased expression of RELA proteinPMID:32147540
Relaincreases expressionISORELA (Homo sapiens)6480464CTDCalcitriol results in increased expression of RELA mRNAPMID:19748465
Relamultiple interactionsISORELA (Homo sapiens)6480464CTDCalcitriol inhibits the reaction [IL1B protein results in increased phosphorylation of RELA protein]; Calcitriol inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein]; RELA protein promotes the reaction [Calcitriol results in increased activity of VDR protein]; RELA protein promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]PMID:18515093 PMID:20206692 PMID:22615136
Relamultiple interactionsISORela (Rattus norvegicus)6480464CTD2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Calcitriol inhibits the reaction [Streptozocin results in increased expression of and results in decreased phosphorylation of RELA protein]]; Calcitriol inhibits the reaction [Streptozocin results in increased expression of and results in decreased phosphorylation of RELA protein]PMID:29953732
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