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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345576
Species: Homo sapiens
RGD Object: Gene
Symbol: DUSP5
Name: dual specificity phosphatase 5
Acc ID: CHEBI:17823
Term: calcitriol
Definition: A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.
Chemical ID: MESH:D002117
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
DUSP5increases expressionEXP 6480464CTDCalcitriol results in increased expression of DUSP5 mRNAPMID:16002434 PMID:21592394
DUSP5multiple interactionsEXP 6480464CTD[Testosterone co-treated with Calcitriol] results in increased expression of DUSP5 mRNAPMID:21592394
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