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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1314687
Species: Homo sapiens
RGD Object: Gene
Symbol: SERPINB1
Name: serpin family B member 1
Acc ID: CHEBI:17823
Term: calcitriol
Definition: A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.
Chemical ID: MESH:D002117
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SERPINB1increases expressionEXP 6480464CTDCalcitriol results in increased expression of SERPINB1 mRNAPMID:15951637 PMID:16002434 PMID:16847355 PMID:26485663
SERPINB1multiple interactionsEXP 6480464CTDKetoconazole promotes the reaction [Calcitriol results in increased expression of SERPINB1 mRNA]PMID:26485663
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