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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11186
Species: Mus musculus
RGD Object: Gene
Symbol: Pth
Name: parathyroid hormone
Acc ID: CHEBI:17823
Term: calcitriol
Definition: A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.
Chemical ID: MESH:D002117
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pthaffects chemical synthesisISOPTH (Homo sapiens)6480464CTDPTH protein affects the chemical synthesis of CalcitriolPMID:15891005
Pthaffects expressionISOPTH (Homo sapiens)6480464CTDCalcitriol affects the expression of PTH proteinPMID:8711172
Pthdecreases expressionISOPth (Rattus norvegicus)6480464CTDCalcitriol results in decreased expression of PTH mRNA; Calcitriol results in decreased expression of PTH proteinPMID:11305809 PMID:12399635 PMID:1453499 PMID:16316325 PMID:17444814
Pthdecreases expressionISOPTH (Homo sapiens)6480464CTDCalcitriol results in decreased expression of PTH mRNA; Calcitriol results in decreased expression of PTH proteinPMID:10027919 PMID:12369129 PMID:12631365 PMID:15956805 PMID:16189633 PMID:1752077 PMID:17984431 PMID:2051637 PMID:21985997 PMID:3626302 PMID:6760236 PMID:7847357 PMID:8052367 PMID:8261678 PMID:8807625 PMID:9263752
Pthdecreases secretionISOPth (Rattus norvegicus)6480464CTDCalcitriol results in decreased secretion of PTH proteinPMID:16316325
Pthdecreases secretionISOPTH (Homo sapiens)6480464CTDCalcitriol results in decreased secretion of PTH proteinPMID:21350317
Pthmultiple interactionsISOPth (Rattus norvegicus)6480464CTDCalcium affects the reaction [Calcitriol results in decreased expression of PTH mRNA]; Calcium affects the reaction [Calcitriol results in decreased secretion of PTH protein]PMID:16316325
Pthmultiple interactionsISOPTH (Homo sapiens)6480464CTD[Calcitriol co-treated with Calcium] results in decreased expression of PTH proteinPMID:80633
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