Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	10983
Species:	Mus musculus
RGD Object:	Gene
Symbol:	Ngfr
Name:	nerve growth factor receptor (TNFR superfamily, member 16)

Acc ID:	CHEBI:17823
Term:	calcitriol
Definition:	A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.
Chemical ID:	MESH:D002117

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Ngfr	affects activity	ISO	Ngfr (Rattus norvegicus)	6480464	CTD	Calcitriol affects the activity of NGFR promoter	PMID:8883959
Ngfr	decreases expression	ISO	Ngfr (Rattus norvegicus)	6480464	CTD	Calcitriol results in decreased expression of NGFR mRNA	PMID:8883959
Ngfr	increases expression	ISO	Ngfr (Rattus norvegicus)	6480464	CTD	Calcitriol results in increased expression of NGFR mRNA; Calcitriol results in increased expression of NGFR protein	PMID:8883959
Ngfr	increases expression	ISO	NGFR (Homo sapiens)	6480464	CTD	Calcitriol results in increased expression of NGFR mRNA	PMID:26485663

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